Drug interactions
Fentanyl iontophoretic transdermal system + Prochlorperazine
Severity: Major
Fentanyl iontophoretic transdermal system and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine adds sedative and hypotensive effects to those of fentanyl, and the combination can cause profound sedation, respiratory depression, coma or death. The risk is highest in opioid-naive, elderly or debilitated patients.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression through opioid receptor agonism plus phenothiazine sedation and alpha-adrenergic blockade.
What to do
Reserve the combination for patients without adequate alternatives and use the lowest effective doses. Monitor sedation, respiratory rate and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Prochlorperazine?
MediHelp rates the interaction as major. Fentanyl iontophoretic transdermal system and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prochlorperazine adds sedative and hypotensive effects to those of fentanyl, and the combination can cause profound sedation, respiratory depression, coma or death. The risk is highest in opioid-naive, elderly or debilitated patients.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without adequate alternatives and use the lowest effective doses. Monitor sedation, respiratory rate and blood pressure closely.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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