Drug interactions
Fentanyl iontophoretic transdermal system + Propofol
Severity: Major
Fentanyl iontophoretic transdermal system and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl from the iontophoretic system adds to the sedative and respiratory depressant effects of propofol. Hypotension and apnea may occur during sedation or anesthesia.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and propofol's GABAergic action.
What to do
Use reduced, titrated propofol doses and monitor respiration and blood pressure continuously. Keep airway support available, including in recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propofol
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Propofol?
MediHelp rates the interaction as major. Fentanyl iontophoretic transdermal system and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fentanyl from the iontophoretic system adds to the sedative and respiratory depressant effects of propofol. Hypotension and apnea may occur during sedation or anesthesia.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced, titrated propofol doses and monitor respiration and blood pressure continuously. Keep airway support available, including in recovery.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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