Drug interactions
Fentanyl transdermal + Propofol
Severity: Major
Fentanyl transdermal and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal fentanyl provides ongoing opioid exposure that adds to propofol-induced sedation, respiratory depression and hypotension. Dose requirements for propofol are typically lower.
What this interaction means in plain words
Fentanyl transdermal and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and propofol's GABAergic action.
What to do
Reduce propofol dosing and titrate slowly while monitoring capnography, oxygen saturation and blood pressure. Continue monitoring after the procedure because the patch keeps releasing fentanyl.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propofol
Frequently asked questions
Can I take Fentanyl transdermal with Propofol?
MediHelp rates the interaction as major. Fentanyl transdermal and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Transdermal fentanyl provides ongoing opioid exposure that adds to propofol-induced sedation, respiratory depression and hypotension. Dose requirements for propofol are typically lower.
How serious is the interaction between Fentanyl transdermal and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce propofol dosing and titrate slowly while monitoring capnography, oxygen saturation and blood pressure. Continue monitoring after the procedure because the patch keeps releasing fentanyl.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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