Drug interactions
Ferric maltol + Methyldopa
Severity: Moderate
Ferric maltol and Methyldopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron reduces the absorption of methyldopa, which can lessen its antihypertensive effect. Blood pressure control may deteriorate when iron is started.
What this interaction means in plain words
Ferric maltol and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferric maltol belongs to Miscellaneous; Methyldopa belongs to Cardiovascular.
Why it happens
Iron chelates methyldopa in the gut lumen, reducing its oral absorption.
What to do
Separate doses by at least 2 hours, and monitor blood pressure. Adjust the methyldopa dose if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Other interactions of Ferric maltol
- Aluminum hydroxide + Ferric maltol Moderate
- Calcium carbonate + Ferric maltol Moderate
- Calcium + Ferric maltol Moderate
- Carbidopa-entacapone-levodopa + Ferric maltol Moderate
- Carbidopa-levodopa + Ferric maltol Moderate
- Cimetidine + Ferric maltol Moderate
Frequently asked questions
Can I take Ferric maltol with Methyldopa?
MediHelp rates the interaction as moderate. Ferric maltol and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron reduces the absorption of methyldopa, which can lessen its antihypertensive effect. Blood pressure control may deteriorate when iron is started.
How serious is the interaction between Ferric maltol and Methyldopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours, and monitor blood pressure. Adjust the methyldopa dose if control is lost.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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