Drug interactions
Ferrous sulfate + Liothyronine
Severity: Moderate
Ferrous sulfate and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron can bind thyroid hormone in the gut and reduce its absorption. This may cause hypothyroid symptoms or a rise in TSH in patients on stable replacement.
What this interaction means in plain words
Ferrous sulfate and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous sulfate belongs to Miscellaneous; Liothyronine belongs to Endocrine.
Why it happens
Iron forms insoluble complexes with thyroid hormone in the gut, reducing absorption.
What to do
Separate doses by at least 4 hours. Check TSH and thyroid hormone levels after starting or stopping iron.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ferrous sulfate and Liothyronine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ferrous sulfate
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Ferrous sulfate with Liothyronine?
MediHelp rates the interaction as moderate. Ferrous sulfate and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron can bind thyroid hormone in the gut and reduce its absorption. This may cause hypothyroid symptoms or a rise in TSH in patients on stable replacement.
How serious is the interaction between Ferrous sulfate and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 4 hours. Check TSH and thyroid hormone levels after starting or stopping iron.
What other medicines interact with Ferrous sulfate?
MediHelp also lists interactions of Ferrous sulfate with, for example, Ciprofloxacin, Dimercaprol, Acetohydroxamic acid. The full list is on the Ferrous sulfate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
