Drug interactions
Fesoterodine + Trimipramine
Severity: Moderate
Fesoterodine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant with substantial anticholinergic activity, so combined use increases dry mouth, constipation, urinary retention, confusion and tachycardia. Trimipramine is also metabolized by CYP2D6, but the main concern is additive antimuscarinic burden.
What this interaction means in plain words
Fesoterodine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects, especially in elderly patients, and consider a less anticholinergic antidepressant if they develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Fesoterodine with Trimipramine?
MediHelp rates the interaction as moderate. Fesoterodine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a tricyclic antidepressant with substantial anticholinergic activity, so combined use increases dry mouth, constipation, urinary retention, confusion and tachycardia. Trimipramine is also metabolized by CYP2D6, but the main concern is additive antimuscarinic burden.
How serious is the interaction between Fesoterodine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in elderly patients, and consider a less anticholinergic antidepressant if they develop.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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