Drug interactions
Fexinidazole + Medroxyprogesterone
Severity: Moderate
Fexinidazole and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and increase medroxyprogesterone exposure. This could intensify progestin adverse effects, though the clinical impact is likely modest.
What this interaction means in plain words
Fexinidazole and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing medroxyprogesterone clearance.
What to do
Monitor for progestin adverse effects such as fluid retention, mood change or bleeding changes during the short course. Adjust the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Fexinidazole with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Fexinidazole and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and increase medroxyprogesterone exposure. This could intensify progestin adverse effects, though the clinical impact is likely modest.
How serious is the interaction between Fexinidazole and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestin adverse effects such as fluid retention, mood change or bleeding changes during the short course. Adjust the dose if needed.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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