Drug interactions
Fexinidazole + Montelukast
Severity: Minor
Fexinidazole and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4, but montelukast is mainly cleared by CYP2C8 with contributions from CYP3A4 and CYP2C9, so a large rise in exposure is unlikely. Montelukast has a wide therapeutic margin, so any increase is likely to be of little clinical consequence.
What this interaction means in plain words
Fexinidazole and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by fexinidazole slightly reducing a minor montelukast clearance pathway.
What to do
No dose change is needed; monitor for montelukast adverse effects such as headache or neuropsychiatric symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Fexinidazole with Montelukast?
MediHelp rates the interaction as minor. Fexinidazole and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexinidazole may inhibit CYP3A4, but montelukast is mainly cleared by CYP2C8 with contributions from CYP3A4 and CYP2C9, so a large rise in exposure is unlikely. Montelukast has a wide therapeutic margin, so any increase is likely to be of little clinical consequence.
How serious is the interaction between Fexinidazole and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for montelukast adverse effects such as headache or neuropsychiatric symptoms.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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