Drug interactions
Fexinidazole + Propofol
Severity: Moderate
Fexinidazole and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval, and propofol has little direct QT effect but may contribute to arrhythmic risk in susceptible patients. Fexinidazole may also induce CYP2B6, which contributes only minimally to propofol clearance.
What this interaction means in plain words
Fexinidazole and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole causes QT prolongation and weak CYP2B6 induction; propofol's contribution is small.
What to do
Check ECG and electrolytes before sedation in patients on fexinidazole and monitor the ECG during the procedure. Titrate propofol to clinical effect without pre-emptive dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Fexinidazole with Propofol?
MediHelp rates the interaction as moderate. Fexinidazole and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole can prolong the QT interval, and propofol has little direct QT effect but may contribute to arrhythmic risk in susceptible patients. Fexinidazole may also induce CYP2B6, which contributes only minimally to propofol clearance.
How serious is the interaction between Fexinidazole and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before sedation in patients on fexinidazole and monitor the ECG during the procedure. Titrate propofol to clinical effect without pre-emptive dose changes.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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