Drug interactions
Fexinidazole + Riluzole
Severity: Moderate
Fexinidazole and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its active metabolites may inhibit CYP1A2, the main enzyme metabolizing riluzole. Riluzole levels could increase, raising the risk of dose-related adverse effects including hepatotoxicity, dizziness and nausea.
What this interaction means in plain words
Fexinidazole and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of CYP1A2-mediated riluzole metabolism by fexinidazole.
What to do
Monitor liver transaminases and tolerability of riluzole while fexinidazole is given. Reduce the riluzole dose or suspend it for the short fexinidazole course if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Givosiran + Riluzole Moderate
Frequently asked questions
Can I take Fexinidazole with Riluzole?
MediHelp rates the interaction as moderate. Fexinidazole and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its active metabolites may inhibit CYP1A2, the main enzyme metabolizing riluzole. Riluzole levels could increase, raising the risk of dose-related adverse effects including hepatotoxicity, dizziness and nausea.
How serious is the interaction between Fexinidazole and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver transaminases and tolerability of riluzole while fexinidazole is given. Reduce the riluzole dose or suspend it for the short fexinidazole course if adverse effects appear.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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