Drug interactions
Cannabidiol + Riluzole
Severity: Moderate
Cannabidiol and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riluzole is mainly cleared by CYP1A2, and cannabidiol can affect this enzyme. Riluzole exposure may change unpredictably, with risk of reduced effect or increased adverse effects, including liver enzyme elevation.
What this interaction means in plain words
Cannabidiol and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Riluzole belongs to Miscellaneous.
Why it happens
Cannabidiol can both inhibit and induce CYP1A2, altering riluzole metabolism.
What to do
Monitor liver enzymes and clinical response to riluzole when starting or stopping cannabidiol. Adjust riluzole dose if tolerability or response changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
- Givosiran + Riluzole Moderate
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Riluzole?
MediHelp rates the interaction as moderate. Cannabidiol and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riluzole is mainly cleared by CYP1A2, and cannabidiol can affect this enzyme. Riluzole exposure may change unpredictably, with risk of reduced effect or increased adverse effects, including liver enzyme elevation.
How serious is the interaction between Cannabidiol and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and clinical response to riluzole when starting or stopping cannabidiol. Adjust riluzole dose if tolerability or response changes.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Ciprofloxacin, Elranatamab. The full list is on the Riluzole page.
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