Drug interactions
Givosiran + Riluzole
Severity: Moderate
Givosiran and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran has been shown to raise exposure to sensitive CYP1A2 substrates, and riluzole is mainly cleared by CYP1A2. Higher riluzole levels could increase dose-related adverse effects such as nausea, dizziness and liver enzyme elevations.
What this interaction means in plain words
Givosiran and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Riluzole belongs to Miscellaneous.
Why it happens
Givosiran reduces CYP1A2 activity, decreasing riluzole metabolism.
What to do
Monitor for riluzole adverse effects and liver enzymes. Consider reducing the riluzole dose if tolerability problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Riluzole?
MediHelp rates the interaction as moderate. Givosiran and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran has been shown to raise exposure to sensitive CYP1A2 substrates, and riluzole is mainly cleared by CYP1A2. Higher riluzole levels could increase dose-related adverse effects such as nausea, dizziness and liver enzyme elevations.
How serious is the interaction between Givosiran and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for riluzole adverse effects and liver enzymes. Consider reducing the riluzole dose if tolerability problems arise.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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