Drug interactions
Epcoritamab + Riluzole
Severity: Moderate
Epcoritamab and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab triggers cytokine release that can temporarily suppress CYP enzyme activity. Riluzole is cleared mainly by CYP1A2, so its exposure may rise during and after cytokine release, increasing the risk of adverse effects such as liver enzyme elevation and nausea.
What this interaction means in plain words
Epcoritamab and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Riluzole belongs to Miscellaneous.
Why it happens
Cytokine release from epcoritamab downregulates CYP450 enzymes, reducing metabolic clearance of riluzole.
What to do
Monitor for riluzole adverse effects and liver function tests during the first weeks of epcoritamab step-up dosing and during cytokine release syndrome. Consider riluzole dose reduction or temporary interruption if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
- Givosiran + Riluzole Moderate
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Riluzole?
MediHelp rates the interaction as moderate. Epcoritamab and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab triggers cytokine release that can temporarily suppress CYP enzyme activity. Riluzole is cleared mainly by CYP1A2, so its exposure may rise during and after cytokine release, increasing the risk of adverse effects such as liver enzyme elevation and nausea.
How serious is the interaction between Epcoritamab and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for riluzole adverse effects and liver function tests during the first weeks of epcoritamab step-up dosing and during cytokine release syndrome. Consider riluzole dose reduction or temporary interruption if toxicity occurs.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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