Drug interactions
Ciprofloxacin + Riluzole
Severity: Moderate
Ciprofloxacin and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riluzole is cleared mainly by CYP1A2, which ciprofloxacin inhibits. Riluzole levels may therefore rise, increasing the risk of adverse effects such as nausea, fatigue and liver enzyme elevation.
What this interaction means in plain words
Ciprofloxacin and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Riluzole belongs to Miscellaneous.
Why it happens
Ciprofloxacin inhibits CYP1A2, reducing riluzole metabolism.
What to do
Monitor for riluzole adverse effects and check liver enzymes. Consider an alternative antibiotic if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
- Givosiran + Riluzole Moderate
Frequently asked questions
Can I take Ciprofloxacin with Riluzole?
MediHelp rates the interaction as moderate. Ciprofloxacin and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riluzole is cleared mainly by CYP1A2, which ciprofloxacin inhibits. Riluzole levels may therefore rise, increasing the risk of adverse effects such as nausea, fatigue and liver enzyme elevation.
How serious is the interaction between Ciprofloxacin and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for riluzole adverse effects and check liver enzymes. Consider an alternative antibiotic if toxicity develops.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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