Drug interactions
Fexinidazole + Vilazodone
Severity: Moderate
Fexinidazole and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase vilazodone exposure, raising the risk of dose-related adverse effects.
What this interaction means in plain words
Fexinidazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilazodone.
What to do
Monitor for serotonergic and gastrointestinal adverse effects during the short fexinidazole course, and reduce vilazodone to 20 mg daily if they are not tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Fexinidazole with Vilazodone?
MediHelp rates the interaction as moderate. Fexinidazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may increase vilazodone exposure, raising the risk of dose-related adverse effects.
How serious is the interaction between Fexinidazole and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonergic and gastrointestinal adverse effects during the short fexinidazole course, and reduce vilazodone to 20 mg daily if they are not tolerated.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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