Drug interactions
Fexofenadine + Nifedipine
Severity: Minor
Fexofenadine and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine has been proposed to modulate P-glycoprotein, which could alter fexofenadine absorption. No clinically relevant change in antihistamine effect is expected, and the direction of any effect is uncertain.
What this interaction means in plain words
Fexofenadine and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Nifedipine belongs to Cardiovascular.
Why it happens
Theoretical modulation of P-glycoprotein transport of fexofenadine; the mechanism is not firmly established.
What to do
No dose adjustment is required; reassess antihistamine response only if efficacy or tolerability changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Nifedipine
Frequently asked questions
Can I take Fexofenadine with Nifedipine?
MediHelp rates the interaction as minor. Fexofenadine and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine has been proposed to modulate P-glycoprotein, which could alter fexofenadine absorption. No clinically relevant change in antihistamine effect is expected, and the direction of any effect is uncertain.
How serious is the interaction between Fexofenadine and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; reassess antihistamine response only if efficacy or tolerability changes.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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