Drug interactions
Fexofenadine + Nilotinib
Severity: Minor
Fexofenadine and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein in vitro and could raise exposure to fexofenadine, a P-glycoprotein substrate. The expected increase is modest and fexofenadine has little QT liability, so clinical impact is likely small.
What this interaction means in plain words
Fexofenadine and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Nilotinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of fexofenadine by nilotinib.
What to do
No adjustment is generally needed; monitor for sedation or other antihistamine adverse effects if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Fexofenadine with Nilotinib?
MediHelp rates the interaction as minor. Fexofenadine and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits P-glycoprotein in vitro and could raise exposure to fexofenadine, a P-glycoprotein substrate. The expected increase is modest and fexofenadine has little QT liability, so clinical impact is likely small.
How serious is the interaction between Fexofenadine and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally needed; monitor for sedation or other antihistamine adverse effects if symptoms arise.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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