Drug interactions
Fexofenadine + Sofosbuvir-velpatasvir
Severity: Minor
Fexofenadine and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexofenadine is a substrate of OATP and P-gp transporters, and velpatasvir may increase its plasma levels. Fexofenadine has a wide safety margin, so clinically important effects are unlikely.
What this interaction means in plain words
Fexofenadine and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits OATP1B1, OATP1B3, OATP2B1 and P-gp, which may increase fexofenadine absorption and reduce its clearance.
What to do
No dose adjustment is generally needed. Advise patients to report excessive drowsiness or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Fexofenadine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Fexofenadine and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexofenadine is a substrate of OATP and P-gp transporters, and velpatasvir may increase its plasma levels. Fexofenadine has a wide safety margin, so clinically important effects are unlikely.
How serious is the interaction between Fexofenadine and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Advise patients to report excessive drowsiness or palpitations.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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