Drug interactions
Fexofenadine + Sotorasib
Severity: Minor
Fexofenadine and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib can induce P-glycoprotein and may lower fexofenadine exposure, a P-gp substrate. This could reduce antihistamine efficacy.
What this interaction means in plain words
Fexofenadine and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Sotorasib belongs to Oncology.
Why it happens
P-glycoprotein induction by sotorasib increases fexofenadine efflux and reduces absorption.
What to do
No empirical dose change is needed. Reassess allergy symptom control and adjust therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Fexofenadine with Sotorasib?
MediHelp rates the interaction as minor. Fexofenadine and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib can induce P-glycoprotein and may lower fexofenadine exposure, a P-gp substrate. This could reduce antihistamine efficacy.
How serious is the interaction between Fexofenadine and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Reassess allergy symptom control and adjust therapy if needed.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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