Drug interactions
Finasteride + Primidone
Severity: Minor
Finasteride and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is partly metabolized to phenobarbital and induces CYP3A4, which may lower finasteride concentrations. Clinical impact is likely small and poorly documented.
What this interaction means in plain words
Finasteride and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finasteride belongs to Genitourinary; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increasing finasteride clearance.
What to do
No empirical dose change; reassess finasteride response if long-term co-therapy is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Finasteride
- Finasteride + Levoketoconazole Moderate
- Finasteride + Nefazodone Moderate
- Finasteride + Rifampin Moderate
- Finasteride + St john's wort Moderate
- Amobarbital + Finasteride Minor
- Aprepitant + Finasteride Minor
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Finasteride with Primidone?
MediHelp rates the interaction as minor. Finasteride and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is partly metabolized to phenobarbital and induces CYP3A4, which may lower finasteride concentrations. Clinical impact is likely small and poorly documented.
How serious is the interaction between Finasteride and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; reassess finasteride response if long-term co-therapy is needed.
What other medicines interact with Finasteride?
MediHelp also lists interactions of Finasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Finasteride page.
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