Drug interactions
Amobarbital + Finasteride
Severity: Minor
Amobarbital and Finasteride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces hepatic CYP3A4 and may lower finasteride exposure. The clinical effect is probably small, but reduced response is theoretically possible during long-term barbiturate use.
What this interaction means in plain words
Amobarbital and Finasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Finasteride belongs to Genitourinary.
Why it happens
Barbiturate induction of CYP3A4-mediated finasteride metabolism.
What to do
No routine adjustment is needed. Reassess response to finasteride if prolonged barbiturate therapy is started and symptoms or PSA reduction seem inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Finasteride
- Finasteride + Levoketoconazole Moderate
- Finasteride + Nefazodone Moderate
- Finasteride + Rifampin Moderate
- Finasteride + St john's wort Moderate
- Aprepitant + Finasteride Minor
- Armodafinil + Finasteride Minor
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Finasteride?
MediHelp rates the interaction as minor. Amobarbital and Finasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital induces hepatic CYP3A4 and may lower finasteride exposure. The clinical effect is probably small, but reduced response is theoretically possible during long-term barbiturate use.
How serious is the interaction between Amobarbital and Finasteride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Reassess response to finasteride if prolonged barbiturate therapy is started and symptoms or PSA reduction seem inadequate.
What other medicines interact with Finasteride?
MediHelp also lists interactions of Finasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Finasteride page.
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