Drug interactions
Finasteride + Levoketoconazole
Severity: Moderate
Finasteride and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can substantially increase finasteride exposure. Given finasteride's wide therapeutic margin, serious toxicity is unlikely but adverse effects may increase.
What this interaction means in plain words
Finasteride and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finasteride belongs to Genitourinary; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition by levoketoconazole decreases finasteride clearance.
What to do
Monitor for finasteride adverse effects such as sexual dysfunction and consider whether finasteride is needed during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Finasteride
- Finasteride + Nefazodone Moderate
- Finasteride + Rifampin Moderate
- Finasteride + St john's wort Moderate
- Amobarbital + Finasteride Minor
- Aprepitant + Finasteride Minor
- Armodafinil + Finasteride Minor
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Finasteride with Levoketoconazole?
MediHelp rates the interaction as moderate. Finasteride and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can substantially increase finasteride exposure. Given finasteride's wide therapeutic margin, serious toxicity is unlikely but adverse effects may increase.
How serious is the interaction between Finasteride and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for finasteride adverse effects such as sexual dysfunction and consider whether finasteride is needed during therapy.
What other medicines interact with Finasteride?
MediHelp also lists interactions of Finasteride with, for example, Nefazodone, Rifampin, St john's wort. The full list is on the Finasteride page.
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