Drug interactions
Finerenone + Fosinopril
Severity: Major
Finerenone and Fosinopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise serum potassium, so the combination increases the risk of hyperkalemia, especially in patients with chronic kidney disease or diabetes. Hyperkalemia can cause dangerous arrhythmias.
What this interaction means in plain words
Finerenone and Fosinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Finerenone belongs to Cardiovascular; Fosinopril belongs to Cardiovascular.
Why it happens
ACE inhibition reduces aldosterone, while finerenone blocks the mineralocorticoid receptor, so both decrease renal potassium excretion.
What to do
Check serum potassium before starting and during therapy, and adjust or interrupt finerenone according to its labeled potassium thresholds. Review other potassium-raising agents and supplements.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Fosinopril?
MediHelp rates the interaction as major. Finerenone and Fosinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs raise serum potassium, so the combination increases the risk of hyperkalemia, especially in patients with chronic kidney disease or diabetes. Hyperkalemia can cause dangerous arrhythmias.
How serious is the interaction between Finerenone and Fosinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before starting and during therapy, and adjust or interrupt finerenone according to its labeled potassium thresholds. Review other potassium-raising agents and supplements.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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