Drug interactions
Finerenone + Hydralazine
Severity: Minor
Finerenone and Hydralazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydralazine is not an established CYP3A4 inhibitor, so no meaningful rise in finerenone levels is expected. Finerenone can cause hyperkalemia and may lower blood pressure, so routine potassium and blood pressure monitoring still applies.
What this interaction means in plain words
Finerenone and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finerenone belongs to Cardiovascular; Hydralazine belongs to Cardiovascular.
Why it happens
No established pharmacokinetic mechanism; a CYP3A4 effect of hydralazine is only theoretical, with possible mild additive blood pressure lowering.
What to do
No dose adjustment is needed; monitor serum potassium and blood pressure as routine for finerenone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Hydralazine?
MediHelp rates the interaction as minor. Finerenone and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydralazine is not an established CYP3A4 inhibitor, so no meaningful rise in finerenone levels is expected. Finerenone can cause hyperkalemia and may lower blood pressure, so routine potassium and blood pressure monitoring still applies.
How serious is the interaction between Finerenone and Hydralazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor serum potassium and blood pressure as routine for finerenone.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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