Drug interactions
Finerenone + Ifosfamide
Severity: Moderate
Finerenone and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is not an established CYP3A4 inhibitor, so a pharmacokinetic increase in finerenone exposure is not supported. However, ifosfamide can cause nephrotoxicity, which may independently increase hyperkalemia risk with finerenone.
What this interaction means in plain words
Finerenone and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Ifosfamide belongs to Oncology.
Why it happens
Ifosfamide nephrotoxicity may reduce renal function, additively increasing hyperkalemia risk with finerenone.
What to do
Monitor serum potassium and renal function during ifosfamide courses. Hold or reduce finerenone if potassium rises or renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Ifosfamide?
MediHelp rates the interaction as moderate. Finerenone and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is not an established CYP3A4 inhibitor, so a pharmacokinetic increase in finerenone exposure is not supported. However, ifosfamide can cause nephrotoxicity, which may independently increase hyperkalemia risk with finerenone.
How serious is the interaction between Finerenone and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during ifosfamide courses. Hold or reduce finerenone if potassium rises or renal function declines.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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