Drug interactions
Finerenone + Lisinopril
Severity: Moderate
Finerenone and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both lisinopril and finerenone can raise serum potassium, so combined use increases the risk of hyperkalemia. This is often used intentionally in diabetic kidney disease but needs monitoring, especially with reduced kidney function.
What this interaction means in plain words
Finerenone and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Lisinopril belongs to Cardiovascular.
Why it happens
Additive potassium retention via reduced aldosterone effect and reduced renal potassium excretion.
What to do
Check serum potassium before starting finerenone and periodically thereafter, adjusting or interrupting finerenone per labeling thresholds.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Lisinopril?
MediHelp rates the interaction as moderate. Finerenone and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both lisinopril and finerenone can raise serum potassium, so combined use increases the risk of hyperkalemia. This is often used intentionally in diabetic kidney disease but needs monitoring, especially with reduced kidney function.
How serious is the interaction between Finerenone and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before starting finerenone and periodically thereafter, adjusting or interrupting finerenone per labeling thresholds.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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