Drug interactions
Finerenone + Moexipril
Severity: Major
Finerenone and Moexipril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise serum potassium, so combining them increases the risk of hyperkalemia, especially in patients with renal impairment or diabetes. Severe hyperkalemia can cause dangerous arrhythmias.
What this interaction means in plain words
Finerenone and Moexipril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Finerenone belongs to Cardiovascular; Moexipril belongs to Cardiovascular.
Why it happens
ACE inhibition lowers aldosterone while finerenone blocks the mineralocorticoid receptor, both reducing renal potassium excretion.
What to do
Check serum potassium and renal function before starting and periodically thereafter. Adjust, interrupt or stop finerenone according to potassium levels as per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Moexipril?
MediHelp rates the interaction as major. Finerenone and Moexipril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs raise serum potassium, so combining them increases the risk of hyperkalemia, especially in patients with renal impairment or diabetes. Severe hyperkalemia can cause dangerous arrhythmias.
How serious is the interaction between Finerenone and Moexipril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function before starting and periodically thereafter. Adjust, interrupt or stop finerenone according to potassium levels as per labeling.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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