Drug interactions
Finerenone + Nifedipine
Severity: Moderate
Finerenone and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure. This increases the risk of hyperkalemia and hypotension.
What this interaction means in plain words
Finerenone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nifedipine reduces finerenone metabolism.
What to do
Monitor serum potassium and renal function when starting or adjusting either drug. Adjust finerenone dose according to potassium results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Nifedipine?
MediHelp rates the interaction as moderate. Finerenone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nifedipine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure. This increases the risk of hyperkalemia and hypotension.
How serious is the interaction between Finerenone and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when starting or adjusting either drug. Adjust finerenone dose according to potassium results.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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