Drug interactions
Finerenone + Nilotinib
Severity: Moderate
Finerenone and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a weak to moderate CYP3A4 inhibitor and can increase finerenone exposure. This raises the risk of hyperkalemia and of reduced renal function in susceptible patients.
What this interaction means in plain words
Finerenone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4, which is the main metabolic pathway of finerenone.
What to do
Monitor serum potassium when starting or adjusting either drug and adjust the finerenone dose according to potassium results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Nilotinib?
MediHelp rates the interaction as moderate. Finerenone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a weak to moderate CYP3A4 inhibitor and can increase finerenone exposure. This raises the risk of hyperkalemia and of reduced renal function in susceptible patients.
How serious is the interaction between Finerenone and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when starting or adjusting either drug and adjust the finerenone dose according to potassium results.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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