Drug interactions
Finerenone + Quinine
Severity: Moderate
Finerenone and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine is a weak CYP3A4 inhibitor and may modestly increase finerenone exposure. This could increase the risk of hyperkalemia and renal effects.
What this interaction means in plain words
Finerenone and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4-mediated metabolism of finerenone by quinine.
What to do
Monitor serum potassium and renal function when starting or changing doses of either drug. Adjust the finerenone dose if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Quinine?
MediHelp rates the interaction as moderate. Finerenone and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine is a weak CYP3A4 inhibitor and may modestly increase finerenone exposure. This could increase the risk of hyperkalemia and renal effects.
How serious is the interaction between Finerenone and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when starting or changing doses of either drug. Adjust the finerenone dose if potassium rises.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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