Drug interactions
Finerenone + Selegiline
Severity: Minor
Finerenone and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline may modestly raise finerenone exposure, increasing the risk of hyperkalemia and hypotension. The effect is likely small.
What this interaction means in plain words
Finerenone and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finerenone belongs to Cardiovascular; Selegiline belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by selegiline reduces finerenone metabolism.
What to do
Monitor serum potassium after starting or changing selegiline. Adjust the finerenone dose according to potassium and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Selegiline?
MediHelp rates the interaction as minor. Finerenone and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selegiline may modestly raise finerenone exposure, increasing the risk of hyperkalemia and hypotension. The effect is likely small.
How serious is the interaction between Finerenone and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium after starting or changing selegiline. Adjust the finerenone dose according to potassium and renal function.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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