Drug interactions
Finerenone + Trandolapril
Severity: Moderate
Finerenone and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce potassium excretion and can raise serum potassium. The combination is used clinically in diabetic kidney disease but hyperkalemia risk is increased, particularly with reduced kidney function.
What this interaction means in plain words
Finerenone and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Trandolapril belongs to Cardiovascular.
Why it happens
Additive hyperkalemia through reduced aldosterone effect (ACE inhibition) and mineralocorticoid receptor antagonism.
What to do
Check serum potassium before starting finerenone and during treatment, and adjust or hold finerenone according to its labeling thresholds.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Trandolapril?
MediHelp rates the interaction as moderate. Finerenone and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs reduce potassium excretion and can raise serum potassium. The combination is used clinically in diabetic kidney disease but hyperkalemia risk is increased, particularly with reduced kidney function.
How serious is the interaction between Finerenone and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before starting finerenone and during treatment, and adjust or hold finerenone according to its labeling thresholds.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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