Drug interactions
Fingolimod + Golimumab
Severity: Moderate
Fingolimod and Golimumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, so using them together may raise the risk of serious infections. Fingolimod's lymphocyte-lowering effect persists for weeks after the last dose, so the overlap can continue after a switch.
What this interaction means in plain words
Fingolimod and Golimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Golimumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from TNF-alpha blockade and sphingosine-1-phosphate receptor modulation with lymphocyte sequestration.
What to do
Avoid routine combined use and monitor closely for signs of infection when switching between them. Check lymphocyte counts and consider the prolonged pharmacodynamic effect of fingolimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Golimumab?
MediHelp rates the interaction as moderate. Fingolimod and Golimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress immune function, so using them together may raise the risk of serious infections. Fingolimod's lymphocyte-lowering effect persists for weeks after the last dose, so the overlap can continue after a switch.
How serious is the interaction between Fingolimod and Golimumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combined use and monitor closely for signs of infection when switching between them. Check lymphocyte counts and consider the prolonged pharmacodynamic effect of fingolimod.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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