Drug interactions
Fingolimod + Ocrelizumab
Severity: Moderate
Fingolimod and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce immune function, so concurrent use may increase the risk of infections, including serious ones. Fingolimod effects on lymphocytes persist for weeks after discontinuation.
What this interaction means in plain words
Fingolimod and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Ocrelizumab belongs to Central Nervous System.
Why it happens
Additive immunosuppression from S1P receptor modulation and B-cell depletion.
What to do
Avoid planned overlap; when switching, monitor lymphocyte counts and watch for infection, accounting for the lingering effects of fingolimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Fingolimod with Ocrelizumab?
MediHelp rates the interaction as moderate. Fingolimod and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs reduce immune function, so concurrent use may increase the risk of infections, including serious ones. Fingolimod effects on lymphocytes persist for weeks after discontinuation.
How serious is the interaction between Fingolimod and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid planned overlap; when switching, monitor lymphocyte counts and watch for infection, accounting for the lingering effects of fingolimod.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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