Drug interactions
Fingolimod + Panobinostat
Severity: Major
Fingolimod and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat markedly prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs. Fingolimod adds bradycardia and QT effects, raising the risk of torsades de pointes.
What this interaction means in plain words
Fingolimod and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Panobinostat belongs to Oncology.
Why it happens
Additive QTc prolongation with fingolimod-induced bradycardia.
What to do
Avoid the combination. If it cannot be avoided, monitor ECG and electrolytes closely, correct potassium and magnesium, and hold panobinostat for significant QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Fingolimod with Panobinostat?
MediHelp rates the interaction as major. Fingolimod and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat markedly prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs. Fingolimod adds bradycardia and QT effects, raising the risk of torsades de pointes.
How serious is the interaction between Fingolimod and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it cannot be avoided, monitor ECG and electrolytes closely, correct potassium and magnesium, and hold panobinostat for significant QTc prolongation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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