Drug interactions
Fingolimod + Sevoflurane
Severity: Moderate
Fingolimod and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval and fingolimod can slow heart rate. Together they may increase perioperative risk of bradycardia and ventricular arrhythmia.
What this interaction means in plain words
Fingolimod and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarisation and heart rate.
What to do
Monitor the ECG continuously during anesthesia and correct potassium and magnesium beforehand. Have treatment for bradycardia available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Fingolimod with Sevoflurane?
MediHelp rates the interaction as moderate. Fingolimod and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval and fingolimod can slow heart rate. Together they may increase perioperative risk of bradycardia and ventricular arrhythmia.
How serious is the interaction between Fingolimod and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG continuously during anesthesia and correct potassium and magnesium beforehand. Have treatment for bradycardia available.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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