Drug interactions
Fingolimod + Tiotropium-olodaterol
Severity: Moderate
Fingolimod and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia after the first dose and can prolong the QT interval. Olodaterol may add to QT and rhythm effects.
What this interaction means in plain words
Fingolimod and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Possible additive effects on cardiac conduction and repolarization.
What to do
Observe heart rate and ECG during fingolimod initiation. Monitor electrolytes and cardiac symptoms during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Fingolimod and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia after the first dose and can prolong the QT interval. Olodaterol may add to QT and rhythm effects.
How serious is the interaction between Fingolimod and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe heart rate and ECG during fingolimod initiation. Monitor electrolytes and cardiac symptoms during co-therapy.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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