Drug interactions
Flavoxate + Perphenazine
Severity: Moderate
Flavoxate and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has moderate anticholinergic activity that may add to flavoxate's effects, causing dry mouth, constipation, urinary retention and blurred vision. The interaction is generally manageable.
What this interaction means in plain words
Flavoxate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flavoxate belongs to Genitourinary; Perphenazine belongs to Central Nervous System.
Why it happens
Additive anticholinergic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects, particularly in older patients, and reduce doses if urinary retention or confusion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Flavoxate with Perphenazine?
MediHelp rates the interaction as moderate. Flavoxate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has moderate anticholinergic activity that may add to flavoxate's effects, causing dry mouth, constipation, urinary retention and blurred vision. The interaction is generally manageable.
How serious is the interaction between Flavoxate and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly in older patients, and reduce doses if urinary retention or confusion occurs.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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