Drug interactions
Flavoxate + Solifenacin
Severity: Moderate
Flavoxate and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flavoxate has antimuscarinic and smooth muscle relaxant properties. Adding it to solifenacin can increase anticholinergic adverse effects such as dry mouth, constipation, blurred vision and urinary retention.
What this interaction means in plain words
Flavoxate and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flavoxate belongs to Genitourinary; Solifenacin belongs to Genitourinary.
Why it happens
Additive anticholinergic effects.
What to do
Avoid duplicating bladder antispasmodics where possible. Monitor for anticholinergic effects and residual urine if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Frequently asked questions
Can I take Flavoxate with Solifenacin?
MediHelp rates the interaction as moderate. Flavoxate and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flavoxate has antimuscarinic and smooth muscle relaxant properties. Adding it to solifenacin can increase anticholinergic adverse effects such as dry mouth, constipation, blurred vision and urinary retention.
How serious is the interaction between Flavoxate and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicating bladder antispasmodics where possible. Monitor for anticholinergic effects and residual urine if both are used.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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