Drug interactions
Flecainide + Fluphenazine
Severity: Moderate
Flecainide and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval and slow conduction, raising the risk of ventricular arrhythmia. Fluphenazine is also a CYP2D6 substrate and may compete with flecainide metabolism.
What this interaction means in plain words
Flecainide and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and conduction effects with possible CYP2D6 competition.
What to do
Obtain a baseline ECG, monitor QT and QRS intervals, and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Flecainide with Fluphenazine?
MediHelp rates the interaction as moderate. Flecainide and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval and slow conduction, raising the risk of ventricular arrhythmia. Fluphenazine is also a CYP2D6 substrate and may compete with flecainide metabolism.
How serious is the interaction between Flecainide and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, monitor QT and QRS intervals, and keep potassium and magnesium within normal range.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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