Drug interactions
Flecainide + Oxaliplatin
Severity: Moderate
Flecainide and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and electrolyte loss from vomiting or diarrhea, and flecainide is proarrhythmic. Together they may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Flecainide and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Oxaliplatin belongs to Oncology.
Why it happens
Additive effects on repolarization, with chemotherapy-related electrolyte disturbances adding risk.
What to do
Monitor ECG and keep potassium, magnesium and calcium within normal range during chemotherapy. Consider an alternative antiarrhythmic if the QT interval lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Flecainide with Oxaliplatin?
MediHelp rates the interaction as moderate. Flecainide and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation and electrolyte loss from vomiting or diarrhea, and flecainide is proarrhythmic. Together they may increase the risk of ventricular arrhythmia.
How serious is the interaction between Flecainide and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium, magnesium and calcium within normal range during chemotherapy. Consider an alternative antiarrhythmic if the QT interval lengthens.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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