Drug interactions
Flecainide + Solifenacin
Severity: Moderate
Flecainide and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flecainide is a class IC antiarrhythmic that slows cardiac conduction and can be proarrhythmic, while solifenacin may modestly prolong the QT interval. Together they may increase the risk of conduction disturbances or arrhythmia.
What this interaction means in plain words
Flecainide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Solifenacin belongs to Genitourinary.
Why it happens
Additive effects on cardiac conduction and repolarization.
What to do
Obtain an ECG before and after starting the combination and monitor QRS and QTc. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Solifenacin?
MediHelp rates the interaction as moderate. Flecainide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flecainide is a class IC antiarrhythmic that slows cardiac conduction and can be proarrhythmic, while solifenacin may modestly prolong the QT interval. Together they may increase the risk of conduction disturbances or arrhythmia.
How serious is the interaction between Flecainide and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before and after starting the combination and monitor QRS and QTc. Correct potassium and magnesium abnormalities.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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