Drug interactions
Flecainide + Tacrolimus
Severity: Moderate
Flecainide and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval and cause electrolyte disturbances such as hyperkalemia and hypomagnesemia. Flecainide adds proarrhythmic risk, so the combination may increase the chance of ventricular arrhythmia.
What this interaction means in plain words
Flecainide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive effects on repolarization, with tacrolimus-related electrolyte changes adding risk.
What to do
Monitor ECG, potassium and magnesium, and tacrolimus levels. Correct electrolyte abnormalities promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Flecainide with Tacrolimus?
MediHelp rates the interaction as moderate. Flecainide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval and cause electrolyte disturbances such as hyperkalemia and hypomagnesemia. Flecainide adds proarrhythmic risk, so the combination may increase the chance of ventricular arrhythmia.
How serious is the interaction between Flecainide and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and tacrolimus levels. Correct electrolyte abnormalities promptly.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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