Drug interactions
Flecainide + Vorinostat
Severity: Moderate
Flecainide and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat, a histone deacetylase inhibitor, has been associated with QT prolongation, and flecainide can cause proarrhythmia. Combined use may raise the risk of ventricular arrhythmias, especially with electrolyte disturbances.
What this interaction means in plain words
Flecainide and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Vorinostat belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Monitor ECG and correct potassium and magnesium before and during therapy. Reassess the need for flecainide if QTc prolongs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Flecainide with Vorinostat?
MediHelp rates the interaction as moderate. Flecainide and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat, a histone deacetylase inhibitor, has been associated with QT prolongation, and flecainide can cause proarrhythmia. Combined use may raise the risk of ventricular arrhythmias, especially with electrolyte disturbances.
How serious is the interaction between Flecainide and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during therapy. Reassess the need for flecainide if QTc prolongs.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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