Drug interactions
Fleroxacin + Sucralfate
Severity: Moderate
Fleroxacin and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate contains aluminum that binds fluoroquinolones in the gut, reducing fleroxacin absorption and potentially causing treatment failure.
What this interaction means in plain words
Fleroxacin and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation by aluminum in sucralfate and adsorption in the gastrointestinal tract reduces absorption.
What to do
Give oral fleroxacin at least 2 hours before sucralfate, or use a non-interacting alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Frequently asked questions
Can I take Fleroxacin with Sucralfate?
MediHelp rates the interaction as moderate. Fleroxacin and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate contains aluminum that binds fluoroquinolones in the gut, reducing fleroxacin absorption and potentially causing treatment failure.
How serious is the interaction between Fleroxacin and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral fleroxacin at least 2 hours before sucralfate, or use a non-interacting alternative.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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