Drug interactions
Flibanserin + Fluoxetine
Severity: Moderate
Flibanserin and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is a moderate CYP2C19 and weak-to-moderate CYP3A4 inhibitor, and its metabolite norfluoxetine inhibits CYP3A4. Flibanserin exposure may rise, increasing hypotension, syncope and sedation. Additive serotonergic effects are also possible.
What this interaction means in plain words
Flibanserin and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Fluoxetine belongs to Central Nervous System.
Why it happens
Fluoxetine inhibits CYP3A4 and CYP2C19, reducing flibanserin metabolism.
What to do
Monitor for dizziness, hypotension, syncope and sedation, and counsel the patient on these effects. Avoid alcohol and consider an alternative if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Flibanserin with Fluoxetine?
MediHelp rates the interaction as moderate. Flibanserin and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine is a moderate CYP2C19 and weak-to-moderate CYP3A4 inhibitor, and its metabolite norfluoxetine inhibits CYP3A4. Flibanserin exposure may rise, increasing hypotension, syncope and sedation. Additive serotonergic effects are also possible.
How serious is the interaction between Flibanserin and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension, syncope and sedation, and counsel the patient on these effects. Avoid alcohol and consider an alternative if effects are troublesome.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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