Drug interactions
Flibanserin + Hydrochlorothiazide-losartan
Severity: Minor
Flibanserin and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan is only a weak CYP3A4 inhibitor, if at all, so the effect on flibanserin exposure is expected to be small. The relevance of this theoretical interaction is minimal.
What this interaction means in plain words
Flibanserin and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flibanserin belongs to Genitourinary; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by losartan, which is not well established clinically.
What to do
No routine action is needed. Counsel the patient about dizziness and low blood pressure, and avoid alcohol with flibanserin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Flibanserin and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Losartan is only a weak CYP3A4 inhibitor, if at all, so the effect on flibanserin exposure is expected to be small. The relevance of this theoretical interaction is minimal.
How serious is the interaction between Flibanserin and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Counsel the patient about dizziness and low blood pressure, and avoid alcohol with flibanserin.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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