Drug interactions
Flibanserin + Methohexital
Severity: Moderate
Flibanserin and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic causing profound CNS depression, and flibanserin adds sedation, dizziness and hypotension. The combination may deepen sedation and cardiovascular effects.
What this interaction means in plain words
Flibanserin and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Methohexital belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and hypotension.
What to do
Inform the anesthesia team about flibanserin use and monitor sedation depth and blood pressure. Withhold the evening flibanserin dose before procedures involving methohexital.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Flibanserin with Methohexital?
MediHelp rates the interaction as moderate. Flibanserin and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic causing profound CNS depression, and flibanserin adds sedation, dizziness and hypotension. The combination may deepen sedation and cardiovascular effects.
How serious is the interaction between Flibanserin and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about flibanserin use and monitor sedation depth and blood pressure. Withhold the evening flibanserin dose before procedures involving methohexital.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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