Drug interactions
Flibanserin + Methoxsalen
Severity: Moderate
Flibanserin and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen can inhibit CYP enzymes including CYP2A6 and, in some data, CYP3A4. Increased flibanserin exposure could add to hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Methoxsalen belongs to Anti Fungals.
Why it happens
Possible inhibition of CYP3A4 by methoxsalen reduces flibanserin metabolism.
What to do
Monitor for dizziness, hypotension and sedation. Separate alcohol use and counsel the patient on syncope risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Flibanserin with Methoxsalen?
MediHelp rates the interaction as moderate. Flibanserin and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen can inhibit CYP enzymes including CYP2A6 and, in some data, CYP3A4. Increased flibanserin exposure could add to hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension and sedation. Separate alcohol use and counsel the patient on syncope risk.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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