Drug interactions
Flibanserin + Nalbuphine
Severity: Moderate
Flibanserin and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nalbuphine is a sedating opioid agonist-antagonist, and flibanserin also depresses the CNS. Together they may produce additive drowsiness, dizziness and impaired psychomotor function.
What this interaction means in plain words
Flibanserin and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Counsel on sedation and avoidance of driving. Use the lowest effective nalbuphine dose and monitor alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Flibanserin with Nalbuphine?
MediHelp rates the interaction as moderate. Flibanserin and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nalbuphine is a sedating opioid agonist-antagonist, and flibanserin also depresses the CNS. Together they may produce additive drowsiness, dizziness and impaired psychomotor function.
How serious is the interaction between Flibanserin and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoidance of driving. Use the lowest effective nalbuphine dose and monitor alertness.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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